kdelca7470
Forum Mod
Joined: 9/30/2007
Posts: 144 |
Subject: Coming Summer 2008
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BSN NCG-CR is Coming soon! Humans lacking the enzyme Nacetylglutamate
synthase (NAGS), which catalyzes the synthesis of NAG, suff er from
hyper-ammonemia, or high blood ammonia levels.3 Not good! As a means to
potentially treat this condition, researchers found that supplementation
with NAG was ineffective.4 As a result, in order to conquer NAGS defi
ciency, researchers needed to find a molecule that could act as the 'key'
to
the ignition of the urea cycle, CPS-I. On that line, they discovered that
our old friend NCG, (remember, it's a biological analogue of NAG) was the
remedy, as it is an allosteric activating key for CPS-I, allowing the urea
cycle to function without NAG. In addition to this function, NCG also
performs the same role as an allosteric activating key for the enzyme
pyrroline-5- carboxylate synthase (P5CS) in enterocytes, or intestinal
cells. Pyrroline-5-carboxylate (P5C) is an intermediate in Proline (an
amino
acid) synthesis. Th is is important given that a majority of Arginine is
synthesized from the Citrulline and Proline produced in the small
intestine,
and ultimately gets transported to the kidneys and liver respectively.
While
Arginine is not produced in the small intestine, CPS-I is still activated
by
NCG to enable the conversion of carbamoyl phosphate and Ornithine to
Citrulline. Simultaneously, NCG activates P5CS which, similarly, enables
the
conversion of P5C to Proline.
Knowing that a majority of Arginine is synthesized from the amino acids
Citrulline and Proline, and further realizing that NCG plays a role as an
activating key for this process, it should come as no surprise to those
scientifi cally inclined that NCG may play a role in increasing plasma
Arginine concentration. In fact, previous research in the fi eld has
revealed that NCG is a metabolically stable form of N-acetylglutamate, the
molecule that activates carbamoyl phosphate synthase during the urea
cycle.
In 2004, a group of animal scientists evaluated Arginine nutrition in
neonatal piglets and more recently, this same group of scientists
revisited
that same premise by conducting a study on the eff ects of oral NCG
supplementation on muscle protein synthesis in the skeletal muscle of
piglets. Th is newly uncovered research demonstrates that NCG can lead to
an
increased plasma concentration of the amino acids Arginine, Ornithine and
Citrulline. In this particular study, oral administration of NCG on
nursing
piglets was found to increase plasma Arginine concentrations by 32% over
control piglets.2 Th e graph above demonstrates an increase in the
synthesis
of citrulline and arginine from glutamate (left) and from proline (right)
in
NCG versus control piglets.2 Researchers speculated that this increase in
Arginine concentration led to an increase in the growth rate of the pigs.
Now before you get up in arms about why the study was conducted on
piglets,
keep in mind that for years, investigators have used pigs as a model in
biomedical research because of the similarities in physiology to humans.
Recently, researchers at the University of Illinois at Champaign-Urbana
announced the unbelievable similarities between the human and pig
genomes.
NCG also led to increased Somatotropin (a growth hormone [GH] that
stimulates protein synthesis, muscle hypertrophy and lipolysis). Th ese
NCG
eff ects are likely mediated through two mechanisms1) NCG works to improve
the function of the urea cycle, helping to enhance positive nitrogen
balance
while, (2) Simultaneously facilitating the conversion of Ornithine to the
Citrulline that will be converted to Arginine in the kidneys.
So noteworthy is the discovery of this NCG bio-analogue and its role in
muscle growth and athletic performance that BSN is currently formulating
and
beta-testing a new NCG supplement the likes of which have never been seen
before in sports nutrition! NCG-CRT as this product is tentatively named
will mediate its eff ects through hypertrophic muscle activation and
anabolic potentiation, which could very well alter the physiological
mechanisms involved in muscle growth vis á vis protein synthesis! Stay
tuned
to Body & StyleT for more breaking news on NCG-CRT, including results from
the beta-testing sample! |
| Posted: 5/15/2008 |
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bionic redneck
New Poster
Joined: 5/12/2008
Posts: 1
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Subject:
no offense but what is that in simpler terms
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| Posted: 5/12/2008 |
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